Located around 2 km from the 400 berth fully serviced Mayflower Marina, Mayflower Bed & Breakfast Plymouth is around a 5-minute walk from Plymouth Synagogue. Guests who stay at the bed & breakfast can park their car nearby.

The Barbican is not very far away, while Plymouth train station is in the vicinity of this hotel. Prysten House in Plymouth is merely 150 metres from the property. Also, Beaumont Park is situated a mere 13 minutes' walk away. The Mayflower Bed & Breakfast Plymouth is within reach of the art deco-style National Marine Aquarium. Buckwell Street bus stop is at a distance of a mere 250 metres from this Plymouth hotel.

The accommodation offers rooms with a sitting area featuring an iron and ironing board, along with a flat-screen TV with satellite channels. Providing a separate toilet and a shower, the bathrooms are also appointed with hairdryers and bath sheets.

Barbican Kitchen is just near Mayflower Bed & Breakfast and specialises in European cuisine.